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DeCS
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Descriptor English:
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N-Myc Proto-Oncogene Protein
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Descriptor Spanish:
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Proteína Proto-Oncogénica N-Myc
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Descriptor Portuguese:
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Proteína Proto-Oncogênica N-Myc
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Synonyms English:
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BHLHE37 Protein
Class E Basic Helix Loop Helix Protein 37
Class E Basic Helix-Loop-Helix Protein 37
MYCN Protein
N Myc Protein
N Myc Proto Oncogene Protein
N-Myc Protein
NMYC Protein
Proto-Oncogene Protein, N-Myc
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Tree Number:
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D12.776.260.103.500.625
D12.776.260.108.092.625
D12.776.624.664.700.158
D12.776.930.125.500.563
D12.776.930.127.092.625
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Definition English:
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A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer. |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56596
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Unique Identifier:
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D000071447
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Occurrence in VHL:
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Similar:
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DeCS
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